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Unlike traditional cognitive training, which often involves repetitive, abstract exercises, VR enables personalized, ecologically valid experiences that may mimic daily activities in a safe, controlled setting (Zhu et al., 2024)

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The resulting impairment in hippocampal neurogenesis disrupts synaptic remodeling and contributes to sustained depressive-like behaviors, underscoring the pivotal role of inflammation-mediated synaptic plasticity deficits in CUMS-induced depression (He et al., 2024)